hidmacros.eu

I am a digital artist who has been using HID Macros to remap keys in a numpad so I can use graphic software such as Photoshop, Sketchbook Pro and similar software.

When I was working these days, I wanted to have one key of this Numpad to remap all the other keys (or switch to a different map that I could set up) when pressed. That way I would be able to do more with just the Numpad and would need the whole keyboard less.

Is there any way I can make it work?

Not without scripting. In LuaMacros easily, but luamacros is all about scripting.
In Hidmacros... I don't remember if there's script command to load different configuration (xml file) but even if there was you would need to write some VB script anyway...